Structure

Laboratory of Macromolecular Crystallography


Vladimir Y. Lunin


Date and place of birth: 12 May 1951, Leningrad, USSR

Degree: Dr.Sci. in Physics and Mathematics

Current position: Head of Laboratory of Macromolecular Crystallography, Institute of Mathematical Problems of Biology RAS

Education

1968-1973 - graduate student of the Moscow State University (department of Mathematics and Mechanics); the master degree thesis: "On the stability of evolutional differential equations in Banach spaces".

1973-1976 - postgraduate student of the Moscow State University (department of Mathematics).

Degrees

1977 - Ph.D. degree awarded by the Moscow State University in mathematics for the thesis "The asymptotic behaviour of the solutions of singular perturbated partial differential equations";

1992 - Dr.Sci. degree awarded by the Institute of Crystallography of Russian Academy of Sciences (Moscow) in crystallography for the thesis "The use of electron density histograms for solution of the phase problem in protein crystallography".

Previous positions:

  • from 1990 - Head of Laboratory of Macromolecular Crystallography; IMPB RAS, Pushchino;
  • 1995-1996 - professor of the department of applied mathematics of the Pushchino State University;
  • 1990-1993 - deputy director of the Institute of Mathematical Problems of Biology, Pushchino;
  • 1982-1990 - senior research fellow of the Research Computing Center of USSR Academy of Sciences, Pushchino;
  • 1976-1982 - junior research fellow of the Research Computing Center of USSR Academy of Sciences, Pushchino;
  • 1973-1975 teacher of mathematical analysis at the department of mathematics and mechanics of Moscow State University.

Research interests:

  • the spatial structure of biological macromolecules;
  • methods of structure analysis;
  • mathematical and computer problems of X-ray structure analysis;
  • development of software for molecular biology studies.

Awards, fellowships:

  • 1993 - Kapitza Fellowship awarded by the Royal Society (United Kingdom);
  • 1993 - individual grant of International Science Foundation;
  • 1993 - individual grant of ACA/USNCCr Fund;
  • 1994-1996 - Russian state research fellowship;
  • 1997-1999 - Russian state research fellowship;
  • 2000-2002 - Russian state research fellowship.

Grants (Principal Investigator):

  • 1989-1991 - grant of the Scientific Council "Cell-free protein synthesis";
  • 1992-1994 - grant of the Scientific Council "Cell-free protein synthesis";
  • 1992 - support by the collaborative program of Russian Academy of Sciences and the Royal Society (United Kingdom);
  • 1993-1994 - grant of ACA/USNCCr Fund;
  • 1994 - grant RMZ000 of International Science Foundation;
  • 1995 - grant RMZ300 of International Science Foundation;
  • 1994-1996 - grant 94-04-12844 of Russian Foundation for Basic Researches;
  • 1997-1999 - grant 97-04-48319 of Russian Foundation for Basic Researches;
  • 2000-2002 - grant 00-04-48175 of Russian Foundation for Basic Researches;
  • 1993-2002 - support by the collaborative program of Russian Academy of Sciences and National Centre for Scientific Researches (CNRS, France);
  • 2002-2003 - grant 02-02 of French-Russian Institute A.M.Liapunov of Informatics and Applied Mathematics;
  • 2003-2005 - grant 03-04-48155 of Russian Foundation for Basic Researches.

Projects participation:

Projects details

  • Phase improvement and extension of Fourier syntheses resolution.
  • The development of an ab-initio procedure for solution of the crystallographic phase problem starting from the low resolution.
  • The use of the maximal likelihood principle in protein crystallography.
  • The development of crystallographic software.
  • The determination of structures of biological macromolecules.
  • The Fast Differentiation Algorithm and its applications in macromolecular crystallography.
  • The use of Fourier syntheses histograms for solution of the phase problem in protein crystallography.
  • The use of the connectivity properties of high-density regions for solution of the phase problem in macromolecular crystallography.
  • The development of Few Atoms Model method for solution of the phase problem in protein crystallography.
  • Ab-initio low-resolution phasing in crystallography of macromolecules by maximisation of the likelihood.
  • A statistical approach to the estimates of errors in the phases calculated from a preliminary atomic models.
  • Likelihood-base refinement of atomic models.

Publications:

More then 150 publications including more then 90 full articles.

The list of publications

The full texts of papers

E-mail:

lunin@impb.psn.ru

Postal address:

Lunin V.Yu.
Institute of Mathematical Problems of Biology RAS,
Pushchino, Moscow Region,
142290, Russia