Laboratory of Macromolecular Crystallography
Alexandre G. Urzhumtsev
Date and place of birth:
07 August, 1956, Osa, Permskaya reg.
Ph.D. in physics and mathematics (with specialization in crystallography)
Habilitation a Diriger des Recherches (French second-level dissertation)
professor, University Henri Poincare, Nancy, France
1971-1973 - Specialized in physics and mathematics boarding school by Acad. A.N.Kolmogorov at MSU;
1973-1978 - Moscow State University, department of Computational Mathematics and Cybernetics;
University diploma for the project "A generalization of the Bernstein inequality"
1985 - PhD degree awarded by the Moscow Institute of Crystallography for the thesis
"Phase improvement in protein crystallography by the method of mixed atomic model ".
1997 - University of Strasbourg, France; Habilitation a Diriger des Recherches (French second-level dissertation):
Title: "Development of methods and programs for macromolecular structure determination by X-ray crystallography"
- 1997 - till now - professor, University Henri Poincare, Nancy,
- 1991-1997- researcher, UPR 9004 (IBMC / IGBMC), Strasbourg,
- 1995 - 1996 (3 months)- invited researcher, NY University Medical Centre, New York,
- 1994 (3 months)- invited researcher, Max-Planck-Institute, Hamburg,
- 1991-1997 - senior researcher, Institute of Mathematical Problems of Biology (till 1992 named Research Computer Center, Russian Academy of Sciences,
- 1986-1991 - researcher at the same institute,
- 1982-1986 - junior researcher at the same institute,
- 1978-1982- engineer-researcher at the same institute,
- 1978- postdoctoral student at the same institute.
- methodological problems of macromolecular crystallography
- determination of difficult macromolecular structures
- development of crystallographic software
Grants (LMC, participant):
- 1989-1991 grant of the Scientific Council "Cell-free protein synthesis";
- 1992-1994 grant of the Scientific Council "Cell-free protein synthesis";
- The development of an ab-initio procedure for solution of the crystallographic phase problem starting from the low resolution.
- The use of the maximal likelihood principle in protein crystallography.
- The development of crystallographic software.
- The Fast Differentiation Algorithm and its applications in macromolecular crystallography.
- The determination of structures of biological macromolecules.
- The use of Fourier syntheses histograms for solution of the phase problem in protein crystallography.
- The use of the connectivity properties of high-density regions for solution of the phase problem in macromolecular crystallography.
- The development of Few Atoms Model method for solution of the phase problem in protein crystallography.
- A statistical approach to the estimates of errors in the phases calculated from a preliminary atomic models.
- Likelihood-base refinement of atomic models.
- Phase improvement and extension of Fourier syntheses resolution
More then 150 publications including more then 80 full articles.
The list of publications.
The full texts of papers.