Laboratory of Macromolecular Crystallography

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Alexandre G. Urzhumtsev

Date and place of birth: 07 August, 1956, Osa, Permskaya reg.

Degree: Ph.D. in physics and mathematics (with specialization in crystallography)
Habilitation a Diriger des Recherches (French second-level dissertation)

Position: professor, University Henri Poincare, Nancy, France

Education

1971-1973 - Specialized in physics and mathematics boarding school by Acad. A.N.Kolmogorov at MSU;
1973-1978 - Moscow State University, department of Computational Mathematics and Cybernetics; University diploma for the project "A generalization of the Bernstein inequality"

Degrees

1985 - PhD degree awarded by the Moscow Institute of Crystallography for the thesis "Phase improvement in protein crystallography by the method of mixed atomic model ".
1997 - University of Strasbourg, France; Habilitation a Diriger des Recherches (French second-level dissertation): Title: "Development of methods and programs for macromolecular structure determination by X-ray crystallography"

Previous positions:

1997 - till now - professor, University Henri Poincare, Nancy,
1991-1997- researcher, UPR 9004 (IBMC / IGBMC), Strasbourg,
1995 - 1996 (3 months)- invited researcher, NY University Medical Centre, New York,
1994 (3 months)- invited researcher, Max-Planck-Institute, Hamburg,
1991-1997 - senior researcher, Institute of Mathematical Problems of Biology (till 1992 named Research Computer Center, Russian Academy of Sciences,
1986-1991 - researcher at the same institute,
1982-1986 - junior researcher at the same institute,
1978-1982- engineer-researcher at the same institute,
1978- postdoctoral student at the same institute.

Research interests:

methodological problems of macromolecular crystallography
determination of difficult macromolecular structures
development of crystallographic software

Grants (LMC, participant):

1989-1991 grant of the Scientific Council "Cell-free protein synthesis";
1992-1994 grant of the Scientific Council "Cell-free protein synthesis";

Projects participation:

Projects details

The development of an ab-initio procedure for solution of the crystallographic phase problem starting from the low resolution.
The use of the maximal likelihood principle in protein crystallography.
The development of crystallographic software.
The Fast Differentiation Algorithm and its applications in macromolecular crystallography.
The determination of structures of biological macromolecules.
The use of Fourier syntheses histograms for solution of the phase problem in protein crystallography.
The use of the connectivity properties of high-density regions for solution of the phase problem in macromolecular crystallography.
The development of Few Atoms Model method for solution of the phase problem in protein crystallography.
A statistical approach to the estimates of errors in the phases calculated from a preliminary atomic models.
Likelihood-base refinement of atomic models.
Phase improvement and extension of Fourier syntheses resolution

Publications:

More then 150 publications including more then 80 full articles.

The list of publications.

The full texts of papers.

E-mail:

Alexander.Ourjoumtsev@lcm3b.uhp-nancy.fr